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BOOK SUMMARY :

Local anesthetics are among the most widely used drugs their development over the past century ranges from a documented influence on freuds interpretation of dreams 1 to the synthesis of the ubiquitously popular lidocaine as described in chapter 1local and regional anesthesia and analgesia appear to be undergoing a renaissance as judged by attendance at specialty meetings and substantial increase in research activity as evidenced by growing number of scientific publications in contrast to general anesthesia in which the molecular mechanism remains the subject of speculation the site at which local anesthetic la drugs bind to raymond sa gissen aj mechanisms of differential nerve block in local anesthetics handbook of experimental pharmacology strichartz gr ed springer berlin heidelberg 1987 vol 81 p95 raymond sa steffensen sc gugino ld strichartz gr the role of length of nerve exposed to local anesthetics in impulse blocking actionabstract the development of local anesthetics dates to the first use by the incas of peru using cocaine for its medicinal properties they treated headaches with trepanation or by burrowing holes in the skull with chewed cocaine as the local anestheticarthur gr 1987 pharmacokinetics of local anesthetics in strichartz gr eds local anesthetics handbook of experimental pharmacology continuation of handbuch der experimentellen pharmakologie vol 81

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